Promoter Hypermethylation in Prostate Cancer
نویسندگان
چکیده
منابع مشابه
Promoter hypermethylation in prostate cancer.
BACKGROUND The prostate gland is the most common site of cancer and the second leading cause of cancer mortality in American men. It is well known that epigenetic alterations such as DNA methylation within the regulatory (promoter) regions of genes are associated with transcriptional silencing in cancer. Promoter hypermethylation of critical pathway genes could be potential biomarkers and thera...
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Hypermethylation of CpG islands located in the promoter regions of genes is a major event in the development of the majority of cancer types, due to the subsequent aberrant silencing of important tumor suppressor genes. KLOTHO; a novel gene associated primarily with suppressing senescence has been shown to contribute to tumorigenesis as a result of its impaired function. Recently the relevance ...
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ژورنال
عنوان ژورنال: Cancer Control
سال: 2010
ISSN: 1073-2748,1073-2748
DOI: 10.1177/107327481001700405